Women working in certain jobs may be associated with increased risk of ovarian cancer

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Cosmetologists, beauticians and accountants are among specific occupations that may be associated with an increased risk of ovarian cancer, a case-control study published online in the journal reveals. Occupational and environmental medicine.

People working in the trade, retail, apparel and construction industries may also be vulnerable, while cumulative exposure to certain substances such as talcum powder, ammonia, propellant gases, gasoline and bleach is important. The findings suggest that it may play a role.

Few modifiable risk factors for ovarian cancer have been identified. Environmental factors, including those related to the workplace, may increase risk, but relatively few studies have assessed the occupational hazards faced by women, researchers say.

And such studies often fail to account for potential influencing factors or previous work experience, and the relatively small number of participants limits their findings.

To circumvent these problems, researchers drew lifetime employment histories from population-based case-control studies and performed an exploratory analysis examining two dimensions of work environment. Specific occupational exposure.

Participants included participants in the Prevention of Ovarian Cancer of Quebec (PROVAQ) Study, all aged 18-79 years, between 2010 and 2016 after being diagnosed with epithelial ovarian cancer Recruited from seven hospitals in Montreal.

Of those women who met the study’s inclusion criteria, a total of 491 were matched for age and constituency with 897 women without ovarian cancer.

Information on socio-demographic background, medical history, prescription medications, reproductive history, weight and height, lifestyle factors, and lifetime employment history was collected from all participants.

Many women with ovarian cancer were less educated, used oral contraceptives for less time, and had no or fewer children than women in the comparison group. All of these are potential risk factors for this disease.

Participants reported job titles, start and end dates, and dates for each job held for at least six months. Working hours including shift work. Main task to be performed.

Cumulative tenure in a job or industry was then categorized as none, less than 10 years, and more than 10 years.

The Canadian Occupational Exposure Matrix (CANJEM) was used to calculate participants’ exposure to specific factors in the workplace and to determine the relationship between exposure to each of the 29 most common factors and ovarian cancer risk. Rated.

After considering potentially influencing factors, calculations showed that some occupations may be associated with an increased risk of this disease.

Specifically, working as a beautician, barber, beautician, and related occupations for 10 years or more increases the risk three times, working as an accountant for 10 years or more doubles the risk, and working in the construction industry increases the risk. is doubled. Almost three times the risk.

Similarly, long-term work in the clothing industry, including embroidery, was associated with an 85% increased risk of developing the disease, while working in sales and retail was found to increase the risk by 45% and 59%, respectively. bottom.

A greater than 40% increase in risk was observed with high cumulative exposure (≥8 years) compared to no exposure to 18 different agents. These contained talcum powder. ammonia; hydrogen peroxide; hair dust. Synthetic fiber. polyester fiber. Organic dyes and pigments. cellulose; formaldehyde; propellant gases; natural chemicals found in gasoline and bleach.

Hairdressers, beauticians and related workers are the occupations most frequently exposed to 13 substances, including ammonia, hydrogen peroxide, organic dyes and pigments, bleaches, and talcum powder with a frequency of 2 It was the second most popular occupation.

But it’s not clear whether these associations were driven by a single factor, a combination, or other workplace factors, the researchers said.

Number of women employed in specific occupations -;-; papermaking, printing, textile production, dry cleaning, manufacturing -; or including those previously reported as potential ovarian cancer risk factors The number of women who have been exposed to specific pathogens – asbestos and pesticides – researchers acknowledge was small.

And some of the observed statistically significant associations were likely due to chance given the number of analyzes performed, they added. Further studies will be needed to replicate this finding, they stress.

However, they still conclude that the results “suggest that employment in certain occupations and certain occupational exposures may be associated with an increased risk of ovarian cancer.”

The present study concludes that “the lack of representation of women in occupational cancer research, and indeed even potential strategies to address this problem, has been recognized for some time. It reminded me that the study of the risk of cancer still needs improvement,” write Dr. Melissa Friesen and Dr. Laura Bean Freeman of the National Cancer Institute in the linked commentary.

“By excluding women, we miss the opportunity to identify women-specific cancer risk factors, assess whether there are gender-based differences in risk, and study exposures that occur in occupations that are predominantly female. will,” the researchers conclude.

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