Intermittent fasting may help protect the brain from age-related diseases such as Alzheimer’s

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Alzheimer’s disease is becoming more common as the world’s population ages. Alzheimer’s disease is the most common form of dementia. Dementia is a term used to describe a range of conditions associated with age-related decline in brain function. Symptoms include memory loss, communication difficulties, problem-solving difficulties, personality and behavioral changes.

Alzheimer’s disease is an increasingly urgent global problem. The World Health Organization predicts that the number of people with this disease will triple by 2050.

Despite this growing problem, Alzheimer’s disease remains a relatively understudied state. This is especially true for sub-Saharan countries. South Africa. One of the major challenges is that Alzheimer’s disease is a complex condition with no known cure. However, researchers have identified some important risk factors associated with the disease. These include age, genetics, lifestyle factors and underlying medical conditions.

In recent years, one of the most promising areas of research into age-related diseases such as Alzheimer’s disease is the accumulation of toxic proteins in the brain. Specifically, amyloid beta. Amyloid-β remains an important research area in Alzheimer’s disease, as accumulation of amyloid-β is a typical feature in the development of Alzheimer’s disease. Understanding their involvement in disease processes is crucial for advancing knowledge and developing effective strategies for diagnosing, preventing, and treating disease.

Accumulation of amyloid-β can lead to plaque formation. These plaques can interfere with communication between brain cells. This ultimately contributes to cognitive decline and other symptoms associated with Alzheimer’s disease.

Amyloid β is a large membrane protein It is essential for nerve growth and repair. However, later in life its decaying form can destroy nerve cells. This causes the loss of thinking and memory associated with Alzheimer’s disease.

We therefore sought to investigate whether dietary interventions, particularly intermittent fasting, could suppress the accumulation of amyloid-β in the brain and potentially prevent age-related brain cell death.

In a paper published in 2021, my colleagues and I showed that experiments performed in mice found that intermittent fasting suppressed the accumulation of amyloid-β in the brain. These findings were further confirmed in a paper published in May 2022.

Our findings are an important contribution to exploring the potential role of dietary interventions, in which intermittent fasting suppresses the accumulation of amyloid-β in the brain and prevents age-related brain cell death. It is consistent with previous research supporting the idea that it could be helpful. To my knowledge, the most recent study using a variation of intermittent fasting was published in September 2022. The clinical area of ​​this research is still ongoing.

Research into the causes of Alzheimer’s disease has accelerated in recent years, regularly breaking new ground as scientists search for a cure.

Our findings suggest that intermittent fasting may be an effective way to increase the efficiency of autophagy, the process of degrading and recycling damaged or unwanted cellular components such as organelles and toxic proteins. suggesting. This process thus reduces the risk of amyloid-β accumulation and concomitant brain cell death.

These findings are of particular importance as they reveal the relationship between autophagy and age-related brain cell death and the potential therapeutic benefits of interventions targeting this process.


Intermittent fasting is a diet that modulates food intake by alternating periods of fasting and eating. This diet consists of a period of restricted food intake followed by a period of normal eating.

there are different types intermittent fasting. One is a timed diet, where food is consumed within a specific time frame each day. Alternate-day fasting is the practice of restricting food intake every other day.

Intermittent fasting has been shown to have various health benefits. Some of the benefits are also related to promoting brain health.

Our findings show that intermittent fasting is an effective way to increase the efficiency of autophagy, a process essential for removing toxic and misfolded proteins that may accumulate in cells. suggesting that it is possible.

In some cases, autophagy may not function properly to remove harmful proteins and other cellular components from cells. It is thought to be strongly implicated in the development and progression of various age-related diseases and has been the subject of investigation for potential therapeutics.

what we did

In our study, we investigated the effects of intermittent fasting on mouse brain cells and brain cells isolated from mice with increased numbers. amyloid beta toxicity. Mouse cells are frequently used as models for human cells in scientific research. This is due to the striking genetic similarity between mice and humans. The use of this animal model allows researchers to gain valuable insights and test hypotheses. It is generally considered ethically preferable before conducting potentially human studies.

We found that intermittent fasting of mice for 24–48 hours protected specific regions of the brain from cell death. We noted increased autophagy levels in cells from fasted mice. Intermittent fasting preserved autophagic activity even in the presence of large amounts of amyloid-β protein within brain cells. And this process remained effective throughout her 21-day intervention period.

By increasing the efficiency of autophagy, it becomes possible to maintain the removal of harmful proteins in cells even with aging.

The results of this study suggest that interventions such as intermittent fasting may prevent the development of age-related diseases. This has important implications for public health.

Intermittent fasting is a relatively simple dietary intervention and easy to follow. It could be widely adopted as a preventive measure against age-related diseases. These findings also support future research into the mechanism by which intermittent fasting prevents brain cell death, exploring the potential for additional therapeutic interventions targeting autophagy, and evaluating the impact of different fasting regimens on brain health. It also provides a basis for research.

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